In this online, self-learning activity:
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma (NHL), making up just under a third of NHL cases. In the United States, there are roughly 7 cases of DLBCL per 100,000 patients per year. The pathophysiology of DLBCL is complex and not fully understood; but is characterized by a widespread increase of very large, mature B-cells arising from various gene mutations. DLBCL is heterogenous group of tumors and includes many diverse subtypes based on location, presence of other cells within the tumor, and whether the patient has other related illnesses. Advanced age, immunodeficiency, and Epstein-Barr virus are associated risk factors for DLBCL. The disease is considered an AIDS-defining malignancy, marking the point at which an HIV infection is considered AIDS. Diagnosis of DLBCL is made by a tissue biopsy, and morphology and immunophenotyping play a crucial role in determining which subtype of DLBCL a patient has.
This learning activity has been designed to bring HCPs’ knowledge of present and emerging strategies for treatment and management of DLBCL up to date and to improve their competence and performance in treating it.
Hematologists and oncologists; physician assistants, nurse practitioners, pharmacists who practice in oncology, and any other HCPs with an interest in or who clinically encounter patients with DLBCL.
Commercial Support Disclosure: This program is supported by an educational grant from Genmab and AbbVie.
This activity is free of charge.
Release Date: March 22, 2022 -- Expiration Date: March 22, 2023
Faculty: Ranjit Nair, MD
Faculty introduction, disclosures |
Epidemiology and diagnosis of DLBCL · Statistics · Risk factors, pathophysiology · Clinical presentation and staging · Pathologic diagnosis and gene expression profiling · Double and triple expression, including prognostic implications |
Management of DLBCL: Current guidelines, agents, and monitoring · Transplant-eligible vs. non-eligible · Goals of therapy and monitoring parameters · Initial therapy · CD-20 targeting · Therapy specific to molecular subtype · Subpopulations and clinical considerations: Germinal center vs. activated B cell types · Special populations: HIV/AIDS, CD20-negative, central nervous system lymphoma · Disease progression · Chimeric antigen receptor T cells · Chemo- and immunotherapy · Investigational and emerging therapies · Gaps in care · Patient cases |
Summary, conclusions, and best practice recap |
By the end of the session the participant will be able to:
ACCME Activity #201943115
ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review by ScientiaCME.
Faculty Disclosure:
Ranjit Nair, MD, Assistant Professor, The University of Texas MD Anderson Cancer Center, has no relevant financial disclosures.
Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, President of ScientiaCME, has no relevant financial disclosures.
Faculty will discuss off-label uses.
All relevant financial relationships have been mitigated.
ScientiaCME adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.
Commercial Support Disclosure: This program is supported by an educational grant from Genmab and AbbVie.
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