Forgot Password?
Return to Course Listing

CME: Best practices in the real-world clinical management of malignant mesothelioma

Activity Description / Statement of Need:

In this online, self-learning activity:

Malignant mesothelioma (MM) is a relatively rare, aggressive cancer that most commonly affects the pleural space (81%) in cases of malignant pleural mesothelioma (MPM), followed by the peritoneum (9%). Over 80% of MPM patients and 33% of patients with peritoneal MM have a documented prior exposure to asbestos or related minerals. It is thought that the inhaled asbestos fibers interact with mesothelial and inflammatory cells, leading to repeatedly prolonged cell cycles and direct DNA damage. There are three distinct histologic subtypes of MPM, but determining subtypes requires expert assessment and suitable biopsies that are not always available, which may lead to delays in the start of treatment.

Target Audience:

HCPs including: Medical oncologists and pulmonologists; physicians assistants, nurse practitioners, and pharmacists specializing in oncology; and other clinicians who are involved in providing diagnostic and therapeutic services for patients with malignant mesothelioma.

Commercial Support Disclosure: This program is supported by an educational grant from Novocure.

This activity is free of charge.

Release Date: May 04, 2023 -- Expiration Date: May 04, 2024

Faculty: Jae Y. Kim, MD


Introduction, faculty disclosures

Epidemiology, risk factors, and different types of malignant mesothelioma

· Incidence, histology, pathophysiology, and prognosis of mesothelioma

· Risk factors, including asbestos exposure, race, age, gender

· Types of malignant mesothelioma

· Complications and burden associated with malignant mesothelioma

Diagnosis and treatment of malignant mesothelioma

· Guideline-recommended and data-supported updates in the diagnosis and treatment of mesothelioma

· Diagnostic delays, limitations of current diagnostic tools, with an emphasis on imaging techniques and biopsies

·  Present standards of care in the treatment of mesothelioma and limitations, including outcomes

o   Epitheloid vs. nonepitheloid histology

o   PD-1/PD-L1- and CTLA-4-targeting therapy

o   Antifolate plus platinum compound

o   VEGF-targeting

o   Tumor-treating fields

· Emerging investigational therapies: other immune checkpoint inhibitors and targeted therapies

· Patient cases

Summary, conclusion, and best practice gaps

Learning Objectives

By the end of the session the participant will be able to:

  • Describe challenges in the identification and treatment of malignant mesothelioma
  • Identify present and emerging diagnostic and treatment options for malignant mesothelioma
  • Formulate a treatment plan for a patient with malignant mesothelioma


ACCME Activity #202515755

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through ScientiaCME. ScientiaCME is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation: ScientiaCME designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™ toward the AMA Physician's Recognition Award. Physicians should only claim credit commensurate with the extent of their participation in the activity.


ABIM MOC Recognition Statement: Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

ABIM MOC Credit Type: Medical Knowledge

Physicians: For maintenance of certification (MOC) points, you must enter your board certification ID # and birth date correctly.  It is the learner's responsibility to provide this information completely and accurately at the completion of the activity. Without providing it, the learner will NOT receive MOC points for this activity. By providing this data, you acknowledge that it will be shared with ACCME and the applicable certifying board. Please note: Not all activities on this site provide MOC points. If this activity does not specify that it provides MOC points in this section, then it does NOT provide MOC points. This activity provides MOC points only for ABIM.


ScientiaCME is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This activity is approved for 1.0 contact hours (0.1 CEUs) of continuing pharmacy education credit. Proof of participation will be posted to your NABP CPE profile within 4 to 6 weeks to participants who have successfully completed the post-test. Participants must participate in the entire presentation and complete the course evaluation to receive continuing pharmacy education credit. ACPE #0574-0000-23-017-H01-P. This is an Application (A)-type activity. 

PharmacistsYou must enter your NABP # and birth date correctly so that proof of participation can be posted to your NABP CPE profile. It is the learner's responsibility to provide this information completely and accurately at the completion of the activity. Without providing it, the learner will NOT receive CPE credit for this activity.

Nurse Practitioners (NPs): The American Academy of Nurse Practitioners accepts AMA PRA Category 1 Credit(s)™ from organizations accredited by the ACCME. ScientiaCME will provide NPs who successfully complete each activity with a certificate of participation indicating that the activity was designated for AMA PRA Category 1 Credit(s)™.

Faculty Disclosure and Resolution of COI

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review by ScientiaCME.

Disclosure of Faculty: Jae Y. Kim, MD, Chief, Division of Thoracic Surgery, City of Hope National Medical Centerhas received financial compensation from Astra-Zeneca, Eli Lilly and Intuitive for consulting and/or research and/or speaker's bureau work.

Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, President of ScientiaCME, has no relevant financial disclosures.

Faculty WILL NOT discuss off-label uses.

All relevant financial relationships have been mitigated.

ScientiaCME adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Commercial Support Disclosure: This program is supported by an educational grant from Novocure.


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowedge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural and Linguistic Competence

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.

Additional Courses That Are Related To This Activity

Contemporary treatment approaches in the management of graft-versus-host disease (GVHD)

Myeloma bone disease: Monitoring and management

Addressing unmet needs and updates in the pharmacotherapeutic management of alpha-1 antitrypsin deficiency (AATD) and its complications

Optimizing care in advanced non-small cell lung cancer (NSCLC): Zeroing in on personalized medicine with precision