Faculty introduction, disclosures

Introductory content: review of narcolepsy Epidemiology  Etiology: causes  Clinical features, presentation, and classification  Diagnosis and misdiagnosis  Health burden

Screening, diagnosis, and treatment of narcolepsy  Treatment goals  Present and investigational pharmacotherapy, clinical trial findings, and guideline updates, including the roles of:  Stimulants, modafinil, armodafinil  Selective dopamine and norepinephrine reuptake inhibition with solriamfetol  Gamma amino butyric acid metabolites with sodium oxybate / mixed oxybate salts  Histamine H3 receptor inverse agonism  Antidepressant agents  Investigational therapies: status of orexin 2 receptor agonist research  Approaches by severity; targeting excessive daytime sleepiness, cataplexy  Special considerations: pregnancy, lactation, approaches during inpatient care  Non-pharmacological approaches: naps, sleep hygiene  Improving quality of life and minimizing daily disturbances  Patient case(s)

Summary, conclusions, and best practice recap

By the end of the session the participant will be able to:

• Recall the clinical presentation, diagnostic principles, and classification by cause of narcolepsy.
• Describe the diagnosis of narcolepsy and the risks of misdiagnosis.
• Identify present and emerging treatment options for narcolepsy.
• Formulate a treatment plan for a patient with narcolepsy.

ACCME Activity #202396752

ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review by ScientiaCME.

Disclosure of Faculty: Alon Y. Avidan, MD, MPH, FAASM, FAAN, Director, UCLA Sleep Disorders Center, David Geffen School of Medicine at UCLA, has received financial compensation for consulting work and/or speakers bureau from Merck, Idorsia, Takeda, Harmony and Eisai.

Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, President of ScientiaCME, has no relevant financial disclosures.

Faculty WILL NOT discuss off-label uses.

All relevant financial relationships have been mitigated.

ScientiaCME adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Commercial Support Disclosure: This program is supported by educational grants from Harmony Biosciences and Jazz Pharmaceuticals.

• Read the learning objectives above
• Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
• View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
• Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
• Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

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