In this online, self-learning activity:
Over a quarter million women and almost 2,700 men in the U.S. are diagnosed with breast cancer each year, and it is the second leading cause of cancer death in women. The prognosis associated with breast has improved in the last few decades due in large part to earlier detection. However, while detection at the loco-regional stage is associated with a five-year overall survival (OS) rate of 90%, patients with metastatic breast cancer (mBC) may expect five-year OS rates closer to 28%.
Because it is not curable, the goals of care in mBC are: palliation of symptoms, improvement of quality-of-life, and extension of survival. Hormone receptor positivity (HR+) in the absence of human epidermal growth factor receptor 2 overexpression (HER2+) has traditionally conferred a better prognosis. In contrast, HER2+ status is associated with a more negative prognosis, as it is associated with an increase in growth signals that are associated with accelerated tumor growth patterns, faster rates of recurrence, and higher mortality rates.
This activity has been designed to bring healthcare professionals’ knowledge of the rationale behind treatment of HER2+ mBC up to date and to improve their competence and performance in treating it.
Medical oncologists; physician assistants, nurse practitioners, and pharmacists who practice in oncology; and any other healthcare professionals with an interest in or who clinically encounter patients with breast cancer.
Commercial Support Disclosure: This program is supported by an educational grant from Seagen.
This activity is free of charge.
Release Date: February 25, 2022 -- Expiration Date: February 25, 2023
Faculty: Anees Chagpar, MD
Introduction content: Cursory refresher and review of HER2+ mBC
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Management of HER2+ mBC
· Treatment-naïve vs. experienced · HER2-directed therapy · HR+ · Treatment duration · Second- and later-line therapies
· Emerging therapies
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By the end of the session the participant will be able to:
ACCME Activity #201862208
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Faculty Disclosure:
Anees Chagpar, MD, Professor, Department of Surgery, Yale University School of Medicine, is on the Board of Directors for Protean Diagnostics; has received grant or research support from Lumicell; and has received financial compensation as a consultant and/or speaker from Sanofi Aventis, Novartis, Guardant Health, Lumicell, and Puma Diagnostics.
Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, President of ScientiaCME, has no relevant financial disclosures.
Faculty will not discuss off-label uses.
All relevant financial relationships have been mitigated.
ScientiaCME adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.
Commercial Support Disclosure: This program is supported by an educational grant from Seagen.
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