In this online, self-learning activity:
Chronic lymphocytic leukemia (CLL) is a diverse group of hematologic cancers in which B-cells accumulate in the blood, bone marrow, and lymphatic tissue, constituting as absolute lymphocytosis of mature-appearing lymphocytes with an appropriate immunophenotype. Elderly patients comprise the vast majority of those diagnosed with CLL with a median patient age of 71 years. Men have close to twice the risk of women of developing CLL, and there are over 21,000 cases per year, with an annual mortality rate in excess of 4,300. CLL is an indolent disease and often goes undetected for some time. The goals of therapy in treating patients with CLL are achievement and maintenance of prolonged remission while minimizing treatment-related toxicity.
This learning activity has been designed to update healthcare professionals’ knowledge of therapeutic options available for CLL and improve their competence and performance in treating the disease.
The following HCPs: Medical oncologists and hematologists; physician assistants, nurse practitioners, and pharmacists who practice in oncology; and other healthcare professionals who commonly encounter patients with CLL.
Commercial Support Disclosure: This program is supported by an educational grant from Genmab and AbbVie.
This activity is free of charge.
Release Date: July 21, 2021 -- Expiration Date: July 21, 2022
Faculty: Matthew Davids, MD, MMSc
Introduction, disclosures |
Introduction content
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Updates in treatment in patients with CLL [Learning Objectives #2 & 3]
· Risk stratification · Very high risk: del(17p) or TP53 mutations · High risk: no del(17p) / TP53 mutation, unmutated immunoglobulin heavy chain variable (IGHV) · Standard risk: no del(17p) / TP53 mutation, mutated IGHV · Targeted therapy · Bruton tyrosine kinase (BTK) inhibition (ibrutinib) · BCL2 inhibition (venetoclax) · CD-20 targeting (obinutuzumab, ofatumumab) · Chemoimmunotherapy
· Prior treatment regimen(s) · Potential therapies · BTK inhibition (ibrutinib, acalabrutinib) · BCL2 inhibition (venetoclax) · PI3K inhibition (idelalisib, duvelisib) · Chemoimmunotherapy
· Ibrutinib + venetoclax · Chimeric antigen receptor T cells
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Summary, conclusions, and best practice recap |
By the end of the session the participant will be able to:
ACCME Activity #201755572
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Faculty Disclosure: Matthew S. Davids, MD, MMSc, Associate Professor of Medicine, Harvard Medical School, has received financial compensation for grant/research support from: Genentech, Pharmacyclics, TG Therapeutics, Verastem, BMS, MEI Pharma, Surface Oncology, Astra-Zeneca, Ascentage Pharma, Novartis; and honoraria from: AbbVie, Genentech, Janssen, TG Therapeutics, Celgene, Astra-Zeneca, Verastem, Eli Lilly, Adaptive Biosciences, BeiGene, Novartis, Ascentage Pharma, Research to Practice, Takeda.
Off label use and/or investigational use in presentation: venetoclax, duvelisib, acalabrutinib, ibrutinib, obinutuzumab
Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, President of ScientiaCME, has no relevant financial disclosures.
All relevant financial relationships have been mitigated.
ScientiaCME adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.
Commercial Support Disclosure: This program is supported by an educational grant from Genmab and AbbVie.
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