Faculty introduction, disclosures Introduction content: Cursory refresher and review Epidemiology: Statistics by severity, current trends, and associated healthcare costs Causes and risk factors Pathogenesis, including biochemical pathways and their effects on the cell life cycle Clinical features, presentation, histopathology, genetics, and biomarkers Treatment of CRC Developing patient-specific plans to treating mCRC Initial approach · Conventional chemotherapy ± epidermal growth factor receptor inhibition Evolving role of biomarkers’ roles in guiding treatment Present and emerging treatments, including targeted therapies, for mCRC progression beyond first-line therapy · RAS wild-type, BRAF mutations · Antiangiogenic therapy: tyrosine kinase, vascular endothelial growth factor inhibition · Nucleoside analog plus thymidine phosphorylase inhibition · Microsatellite unstable or mismatch repair deficiency · HER2 overexpression · TRK fusion positivity Safety profiles of current and emerging agents and their management [Objectives #2 & 3] Emerging models of care · Putting it all together: integrated, best practice · Patient case(s) [Objectives #2] Summary, conclusions, and best practice recap

By the end of the session the participant will be able to:

• Recall the role of biomarkers in shaping therapeutic decision-making.
• Describe treatment options presently available for mCRC, including optimal treatment sequencing and adverse effect management, and apply them to patient cases, taking into account patient history and tumor characteristics.
• List emerging treatment options for mCRC, their mechanisms of action, safety, and anticipated place in therapy.

ACCME Activity #201718487

ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.

Faculty Disclosure: Kurt A. Melstrom, MD, FACS, FASCRS, Assistant Clinical Professor, City of Hope, has no relevant financial disclosures.

Disclosure of Peer Reviewer: Daniel I-Hsin Chu, MD, FACS, FASCRS, discloses that he has recieved compensation from federal government research grants.

Disclosure of Peer Reviewer: Farshid Dayyani, MD discloses that he has received compensation from research grants and/or consulting fees from Deciphera, Eisai, Excelis, Ipsen, QED,  Signatera, Sirtex, AZD, BMS, Taiho, Merck, Genentech, FIM, Amgen, and Array.

Disclosures of Educational Planners: Charles Turck, PharmD, CEO of ScientiaCME, has no relevant financial disclosures.

Commercial Support Disclosure: This program is supported by educational grants from Merck.

• Read the learning objectives above
• Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
• View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
• Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
• Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

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