Growth hormone deficiency (GHD) is characterized by inadequate secretion of growth hormone by the pituitary gland. The condition may arise from a variety of causes, including tumors, radiation, medications, traumatic brain injury, or genetic defects. In children, GHD is characterized by pronounced short stature, defined as 2 or more standard deviations from the mean based on age and sex. Because short stature may be caused by a variety of other factors, including genetics, hypothyroidism, and Turner syndrome, estimating the prevalence of GYHD in the pediatric population is challenging. Studies suggest that GHD may occur in 1 out of every 4,000 to 10,000 children. There is no gold standard for diagnosis of GHD in children. Clinical practice guidelines from the Pediatric Endocrine Society currently caution against the use of growth hormone provocation testing in the diagnosis of GHD given the unreliability of results. Auxology, biochemical evaluation, imaging, and physical examination remain the cornerstones of GHD diagnosis in children. Clinicians should be aware of appropriate strategies of diagnosis of GHD in pediatric patients, as improper diagnosis may delay effective treatment and increase risk for secondary complications.
The following healthcare professionals: Endocrinologists, pediatricians, and primary care physicians; physician assistants, nurse practitioners, and pharmacists who practice in endocrinology; and any other healthcare professionals with an interest in or who clinically encounter patients with GHD.
This program is supported by an educational grant from Sandoz.
Learners may participate in this activity free of charge.
Release Date: November 19, 2020 -- Expiration Date: November 19, 2022
Faculty: Dennis Styne, MD
Introduction, faculty disclosures
A brief primer: Epidemiologic, pathophysiologic, etiologic features, clinical signs and symptoms
Treatment options available for pediatric GHD
· - Investigational agents: Long-acting (e.g., somapacitan) and needle-less options
Summary, conclusions, and best practice recap
By the end of the session the participant will be able to:
ACCME Activity #201861269
ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.
As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.
Faculty Disclosure: Dennis M. Styne, MD, Yocha Dehe Chair of Pediatric Endocrinology,
University of California, is a stockholder in Bristol Myers Squibb and Teva.
Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, CEO of ScientiaCME, has no relevant conflicts of interest to disclose.
Disclosures of Peer Reviewers:
Michael Gottschalk, MD, PhD has no relevant financial disclosures.
Colin P. Hawkes, MD, PhD has no relevant financial disclosures.
Commercial Support Disclosure: This program is supported by an educational grant from Sandoz.
*Required to view Printable PDF Version
Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.
Medical and nutritional management of eosinophilic esophagitis in adolescents and adults: Therapeutic updates and best practices
Pediatric Crohn's disease: Therapeutic updates and optimizing treatment