In this online CME self-learning program: Systemic sclerosis (SSc) is a rare connective tissue disease that affects between eight and 56 people per million per year and up to 341 people per million total in the U.S., of whom around 70% will experience interstitial lung disease (ILD). The disease is characterized by a progressive course of scarring to the blood vessels underlying the skin, connective tissue, joints, and organs. The pathology of SSc remains to be fully elucidated, but different immunologic and genetic pathways have been explored as potential precipitating factors for SSc. Based on what is known, SSc-ILD may be summarized into three steps: 1) continuous injury to endothelial cells, 2) activation of innate and adaptive immunity, 3) recruitment and activation of fibroblasts. Early diagnosis is crucial for preservation and survival of major organs. Lung fibrosis is considered irreversible, and if the disease has progressed far beyond repair, lung transplantation is considered. Therefore, early detection is paramount in order for patients to preserve their lung function.
The following HCPs: Pulmonologists, rheumatologists, radiologists, primary care physicians, dermatologists; physician assistants, nurse practitioners, nurses, and pharmacists specializing in pulmonology; and any other HCPs who have an interest in or otherwise clinically encounter patients with SSc-ILD.
This program is supported by an educational grant from Mallinckrodt Pharmaceuticals.
Learners may participate in this activity free of charge.
Release Date: October 08, 2020 -- Expiration Date: October 08, 2022
Faculty: Joseph Barney, M.D., MSPH FCCP
Faculty introduction, disclosures
Cursory refresher and review on SSc-ILD epidemiology and diagnosis
Assessment and diagnosis
o HRCT scan: Sensitivity and specificity
o Lung biopsy
Treatment of SSc-ILD
o Corticosteroids, immunomodulators, cyclophosphamide
o Organ rejection
Summary, conclusions, and best practice recap
By the end of the session the participant will be able to:
ACCME Activity #201861265ACCREDITATION FOR THIS COURSE HAS EXPIRED. YOU MAY VIEW THE PROGRAM, BUT CME / CE IS NO LONGER AVAILABLE AND NO CERTIFICATE WILL BE ISSUED.
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Faculty Disclosure: Joseph Barney, MD, MSPH, FCCP, Associate Professor, University of Alabama at Birmingham, has no relevant conflicts of interest to disclose.
Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP, CEO of ScientiaCME, has no relevant conflicts of interest to disclose.
Disclosures of Peer Reviewers:
Joshua Mooney, MD, MS, has received financial compensation for research grants from Boehringer Ingelheim
Zaza Cohen, MD has no relevant conflicts of interest to disclose.
Commercial Support Disclosure: This program is supported by an educational grant from Mallinckrodt Pharmaceuticals.
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