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CME: Therapeutic updates and best practices in the treatment of irritable bowel syndrome with constipation (IBS-C)


Activity Description / Statement of Need:

In this online, self-learning activity:

Irritable bowel syndrome (IBS) is among the most common disorders seen by primary care as well as gastroenterology specialty clinics. Patients with IBS usually present with chronic abdominal pain and altered bowel habit, in the absence of any other disease to cause these sorts of symptoms. Factors such as genetics, immune function, microbiome, psychological and environmental factors could predispose patients to develop of IBS.

Target Audience:

The following healthcare professionals: gastroenterologists and primary care physicians; physician assistants, nurse practitioners, nurses, and pharmacists who practice in gastroenterology; and any other healthcare professionals with an interest in or who clinically encounter patients with IBS-C.

This activity is supported by an educational grant from Synergy.

Release Date: April 30, 2018 -- Expiration Date: April 30, 2020

Faculty: Christopher V. Almario , MD


Introduction content: cursory refresher and review of IBS-C

  • Epidemiology: prevalence/incidence in North America/globally, by age/sex
  • Clinical features and diagnostic criteria of IBS-C

Treatment of IBS-C

  • Clinical trial findings and guideline remarks
  • Present pharmacotherapy
  • Conventional therapies
  • Recent additions: linaclotide, lubiprostone
  • Emerging and future therapies: plecanatide
  • Other clinical pearls
  • Barriers to optimal care in patients with IBS-C: shortfalls in clinical guidelines, Rome criteria, social stigma
  • Patient case(s)

Summary, conclusions, and best practice recap

Learning Objectives

By the end of the session the participant will be able to:

  • Describe what is known about the etiology of IBS-C and its impact on patient clinical presentation
  • Identify symptoms of IBS-C, describe their role in the diagnosis of the disorder, and list* any applicable lab and/or imaging studies that play a role in IBS-C diagnosis
  • Evaluate treatments plans for patients with IBS-C and suggest appropriate therapies, where applicable, based on individual presentations
  • Describe present and emerging drug therapies for management of IBS-C and apply them to patient cases
  • Describe clinical and logistical challenges associated with treating and educating patients with IBS-C


ACCME Activity #201226539


Faculty Disclosure and Resolution of COI

As a provider of continuing medical education, it is the policy of ScientiaCME to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. In accordance with this policy, faculty and educational planners must disclose any significant relationships with commercial interests whose products or devices may be mentioned in faculty presentations, and any relationships with the commercial supporter of the activity. The intent of this disclosure is to provide the intended audience with information on which they can make their own judgments. Additionally, in the event a conflict of interest (COI) does exist, it is the policy of ScientiaCME to ensure that the COI is resolved in order to ensure the integrity of the CME activity. For this CME activity, any COI has been resolved thru content review ScientiaCME.


Faculty Disclosures:


Dr. Christopher V. Almario, M.D., Assistant Professor-in-Residence of Medicine at Cedars-Sinai Medical Center, Los Angeles, CA, is a stock holder in Gilead, Madrigal, Google, Disney, and My Total Health and has received research grant support from Takeda, Novartis, and Shire


Disclosures of Educational Planners: Charles Turck, PharmD, BCPS, BCCCP has no relevant conflicts of interest to disclose.


Commercial Support Disclosure: This activity is supported by an educational grant from Synergy.


  • Read the learning objectives above
  • Take the Pre-Test (optional). Completion of the pre-test will help us evaluate the knowledge gained by participating in this CME activity.
  • View the online activity. You may view this is in more than one session, and may pause or repeat any portion of the presentation if you need to.
  • Minimum participation threshold: Take the post-test. A score of 70% or higher is required to pass and proceed to the activity evaluation.
  • Complete the activity evaluation and CME registration. A CE certificate will be emailed to you immediately.

Cultural/Linguistic Competence & Health Disparities

System Requirements

Windows 7 or above
Internet Explorer 8
*Adobe Acrobat Reader
Mac OS 10.2.8
Safari or Chrome or Firefox
*Adobe Acrobat Reader
Internet Explorer is not supported on the Macintosh

*Required to view Printable PDF Version

Perform Pre-Test (optional)

Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.

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