In this online, self-learning activity:
Hemophilia encompasses a small group of genetic disorders that impair the body’s hemostatic self-regulation mechanisms. Hemophilias A and B, which describe deficiencies in clotting factors VIII and IX, respectively, occur in approximately 1 in 5,000 live male births. Signs and symptoms are not always readily detectable and often escape notice for the first several months of life, but the effects can be life-threatening and may include intracranial hemorrhage, severe bleeding in other organ systems and superficial tissue, and muscoskeletal and intraarticular injury.
The mainstay of hemophilia treatment is clotting factor replacement therapy in the setting of comprehensive care. Recombinant synthesis and blood donor screenings have significantly reduced the once common concern about transmission of infection through pooled donor products, although the development of clotting factors antibodies remain a concern. Other treatments available or in development include other hemostatic and antifibrinolytic medicines and gene therapy.
One contemporary barrier to the optimal treatment of patients may be variability in care due to therapeutic controversies including when to initiate prophylactic therapy and may merit continuing educational programming for strategy elucidation. Another gap is the challenge of continued adherence to therapy, and the healthcare professional may benefit from learning strategies aimed at maintaining and preserving the patient’s commitment to his or her own therapy in the face of obstacles including the necessity for frequent administration.
The following healthcare professionals: hematology, primary care physicians, and pediatricians; physician assistants, nurse practitioners, nurses, and pharmacists who practice in hematology; and any other clinicians with an interest in hemophilia A.
This program is supported by an educational grant from Novo Nordisk.
Release Date: March 17, 2018 -- Expiration Date: March 17, 2020
Faculty: Doris Quon, MD PhD
Faculty introduction, disclosures
Updates in the epidemiology and diagnosis of hemophilia A
Current and emerging treatment options for hemophilia A
Challenges in care in hemophilia A
By the end of the session the participant will be able to:
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Faculty Disclosure: Doris Quon, MD, PhD, Medical Director, Orthopaedic Hemophilia Treatment Center, Los Angeles, CA is a consultant and/or on a Speaker's bureau for Bayer, Bioverativ, Genentech, Novo Nordisk, Shire, Pfizer, Octapharma
Disclosures of Educational Planners: Charles Turck, PharmD has no relevent financial disclosures.
Commercial Support Disclosure: This program is supported by an educational grant from Novo Nordisk.
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Please take a few minutes to participate in the optional pre-test. It will help us measure the knowledge gained by participating in this activity.
Hemophilia B: Therapeutic Updates, Emerging Therapies, and Barriers to Care